If you make use of Design Options in Revit for exploring different alternative designs for the same Project then it is possible to link Rooms within different options Design Options to the one Room in the dRofus Client.
When linking already placed Revit Rooms (see Link Placed / New Revit Rooms to Existing dRofus Rooms and and Link Placed / New Revit Rooms to Created dRofus Rooms), the list of available Rooms will be based upon the currently active Option.
When synchronizing (see Synchronize with Revit) you can optionally only synchronize Rooms within the primary Option as highlighted below:
If you are wanting to synchronize a different Option, then you will need to make that option the primary Option.
dRofus does not accommodate Revit design options, however you can work around this by, for e.g., creating multiple Projects within the same database representing different "Programming" options.
Also, see: Create or Update Revit Rooms from Linked Revit Model and Create or Update Revit Spaces from Linked Revit Model.